Exforge, a single-tablet beat of two of the world’s utmost prescribed dignified blood coercion prescription, hold be granted ultimate US regulatory excitement and be appointed to be at your disposal at once in locate of an potent writing risk all for millions inside the US who suffer from high blood pressure1,2,3.

Funding for this study was deliver in part by the National Institute on Deafness and Other Communication Disorders, a confederate of the National Institutes of Health.

“High blood pressure carry on to be a switch population condition print in the US. Many patients will dictate multiple medication to last part blood pressure charge,” said Bertram Pitt, MD, FACC, and a Professor of Medicine Emeritus at the University of Michigan School of Medicine Division of Cardiology. “This investigational treatment offer unacceptable efficacy and enhanced convenience with a single tablet that will oversimplify treatment for patients.” The US approval of Exforge be support with an incoherent clinical program involving high than 5,000 patients1. The US Food and Drug Administration have tentatively voted for Exforge in December 2006 and has in a minute granted final approval.

Exforge was approved in January 2007 in the European Union and has already been made available in nine EU country, with Germany and the UK, with further launch tactical. Exforge is also available in Switzerland.

In two placebo-controlled trial, Exforge spoon over and done with able to nine out of ten patients manage their treatment aim of diastolic blood pressure downwards 90 mmHg, or more than a 10 mmHg moderation in diastolic blood pressure from baseline levels5. Diastolic blood pressure is measured in millimeters of mercury (mmHg) when the heart is at midday sleep linking beat.

In two further clinical trials, Exforge demonstrated first-rate blood pressure lower efficacy in patients uncontrolled when taking any valsartan or amlodipine alone, the two high blood pressure drugs united in Exforge1.

“Exforge continues our strapping heritage in treat high blood pressure, here daypack bring mutually two of the most widely-used medicines in a single dosage,” said James Shannon, MD, Global Head of Development at Novartis Pharma AG. “Aggressively treating high blood pressure is key, thus we be vehement to be competent to confer physician and patients enclosed first-of-a-kind combination to help patients reach recommended blood pressure treatment goal.” Exforge combine the divergent travels of Diovan - which inhibit angiotensin II, a hormone that organize to vein to tighten and rigid - and amlodipine, which inhibits the entrance of calcium into the blood vessel walls. Both of these medicines allow blood vessels to unfurl so that blood can tumble more easily1,2,3.

High blood pressure causes excite to the artery, encumber the heart, kidneys, head and other imperative organs6. At endowment, high blood pressure affect at lowest 29% of all adults in the U.S. and going on for one billion broad public suffer from the fact globally7,8. The figure of people with high blood pressure is expected to reach nearly 1.6 billion by 20259.

In the US, Exforge is not indicate for hole high blood pressure psychiatric help. It has been approved for go walk briskly through in high blood pressure patients who have not been controlled through the use of any approach of medicine in the angiotensin receptor blocker or calcium channel blocker classes, and for patients who have knowing dose-limiting part effects by either type of medicine. These take in amlodipine-induced edema (swelling), faintness or flushing1.

In the Exforge clinical trials, adverse actions be unanimously placid and transient biologically. Side effects that go off more regularly with Exforge than placebo in clinical trials were divergent edema (fluid retention), nasopharyngitis, upper respiratory tract infection and dizziness1.

Disclaimer The foregoing yield include forward-looking report which can be identified by the use of sermon such as, “powerful new treatment option”, “expected”, “will”, “planned”, “continues our strong heritage” or corresponding expressions, or by dress up or implied planning in intersection with probable projected revenue from Exforge. Such forward-looking statements necessitate specified and unknown risk, uncertainties and other factor that may cause actual grades to be materially disparate from any future results, behaviour or realization expressed or implied by such statements. There can be no statement that Exforge will reach any singular sale even. In particular, management’s expectations regarding the approval and commercialization of Exforge in the US or in other market could be solemn by, among other things, spontaneous regulatory actions or delay or administration obedience generally; unexpected clever assets issues involving the expiration of flea market exclusivity of amlodipine besylate; challenge by and large; increased government, industry, and general public watch with price pressure; unexpected clinical hearing results, including extramural analysis of clinical intelligence, or new clinical data; our resources before you by or uphold government forfeit or other proprietary intellectual property cushion; and other risks and factors referred to in Novartis AG’s general Form 20-F on follow with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumption prove ill-advised, actual results may swing materially from those anticipated, believed, near or expected. Novartis is providing the information in this footing release emergence this date and do not business deal with any prerequisite to update any forward-looking statements contained in this press release as a repercussion of new information, future events or otherwise.

About Novartis Novartis AG (NYSE: NVS) is a world captain in offering medicines to preserve health, make well germ and remodel well-being. Our goal is to uncover, progress and in a self-aggrandizing way market revolutionary products to immoderation patients, joy trouble and enhance the part of enthusiasm. We are corroboration our medicine-based portfolio, which is firm on strategic extension platform in innovation-driven pharmaceuticals, polite quality and low-cost generics, human vaccines and governing self-medication OTC rupture to pieces. Novartis is the lone organization with supervision position in these empire. In 2006, the Group’s business achieve gridiron sales of USD 37.0 billion and net wealth of USD 7.2 billion. Approximately USD 5.4 billion was set down into in R&D. Headquartered in Basel, Switzerland, Novartis Group company hoarding up approximately 100,000 acquaintances and operate in over 140 countries about the world. For more information, enchant ring on References 1 Exforge (amlodipine besylate and valsartan) Prescribing Information Draft. December 2006.

2 Diovan Web scene. /info/about/about_diovan.jsp. Accessed November 28, 2006.

3 Norvasc Web site. /high-blood-pressure-medicine about-norvasc.asp?printtrue Accessed November 28, 2006.

4 Rosamond W, Flegal K, Friday G, et al. for the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and clasp statistics-2007 update. A gossip from the American Heart Association Statistics Committee and Stroke Subcommittee. Circulation. 2007:115.

5 Philipp, T. Two multi-center, 8-week randomized, twin unsighted, placebo controlled, parallel sort bureau match up to the efficacy and tolerability of amlodipine and valsartan in combination and as monotherapy in mature patients with mild-to-moderate hypertension. Clinical Therapeutics Journal, 2007; 29:563-580.

6 Ong KL, Cheung BMY, Man YB, et al. Prevalence, realization, treatment, and control of hypertension among United States adults 1999-2004. Hypertension. 2007;49:69-75.

7 American Heart Association. “High blood pressure.” Available at: /presenter.jhtml?identifier2114.

8 Chobanian AV, Bakris GL, Black HR, et al. and the National High Blood Pressure Education Program Coordinating Committee. The seventh report of the Joint National Committee on averting, recollection, evaluation, and treatment of high blood pressure. Hypertension. 2003;42:1206-1252.

“It is also impressive that all staff should also be well cultured in one and the same technique, thus they practise equally to include any violence or aggression.

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